2014 Transplantatie en Immunologie

FederaDag 2014 Transplantatie en Immunologie

Nieuwe kennis, nieuwe kansen,   Vrijdag 7 november 2014, Erasmus MC Rotterdam.

An impression of FederaDag.

Experts give relevant and quick references on 'Immunosuppression or tolerance: from foreign to own.'

Federa-voorzitter prof. Leendert Looijenga heeft de Federa Awards uitgereikt aan prof. David Sachs (USA) en prof. Kathryn Wood (UK). Deze twee topwetenschappers onderzoeken of bij getransplanteerden tolerantie voor een donororgaan op te wekken is. Deze transplantatietolerantie lijkt een goed alternatief voor afweeronderdrukkende medicijnen. ...naar prijswinnaars


Frans Claas (LUMC Leiden) Short introduction to the alloimmune response in transplantation



Frans Claas (LUMC Leiden)
Short introduction to the alloimmune response in transplantation





De prijswinnaars met de bezoekers van de FederaDag 2014







The specific absence of a destructive immune response to a transplanted tissue in the absence of immunosuppression



Cees van Kooten (LUMC, Leiden)

Cees van Kooten (LUMC, Leiden) 

– The role of dendritic cells
Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities. 

van Kooten C et al. Transplantation. 2011 Jan 15;91(1):2-7. Review Human renal fibroblasts generate dendritic cells with a unique regulatory profile.
Dixon KO, Rossmann L, Kamerling SW, van Kooten C. Immunol Cell Biol. 2014 Sep;92(8):688-98. Abstract


Ineke ten Berge (AMC, Amsterdam)

Ineke ten Berge (AMC, Amsterdam) – The role of T cellsCo-stimulatory pathways, and the important roles of CD4+, Foxp3+, regulatory T cells.

Couser WG. Basic and translational concepts of immune-mediated glomerular diseases. J Am Soc Nephrol. 2012 Mar;23(3):381-99. Abstract




Sebastiaan Heidt  (LUMC, Leiden)



Sebastiaan Heidt (LUMC, Leiden) | B cells in transplantation: it is not all about antibodies Heidt S. et al. B cell markers of operational tolerance can discriminate acute kidney allograft rejection from stable graft function. Transplantation. 2014 Oct 21. Abstract




Attentive public




Attentive public




Irma Joosten (Radboudumc)


Irma Joosten (Radboudumc) | The role of NK cells.
NK cells are cytotoxic lymphocytes of the innate immune system and form a first line defense against tumor cells and infections, but have also the ability to detect HLA class I disparities via killer-cell immunoglobulin-like receptors (KIR).




Van Bergen et al.




Van Bergen et al. KIR-ligand mismatches are associated with reduced long-term graft survival in HLA-compatible kidney transplantation. Am J Transplant. 2011 Sep;11(9):1959-64. Abstract



Kathryn Wood




Kathryn Wood (University of Oxford, UK) Organizing Multicenter study -www.onestudy.org 
One protocol: a unified approach to evaluating cellular immunotherapy in solid organ transplantation.



Pause -  Skyline of Rotterdam




Pause - Skyline of Rotterdam




Board of the Federa



Board of the Federa





Luc van der Laan



Luc van der Laan (Erasmus MC, Rotterdam)





Introduction clinical translation;Sandrine Florquin  Sandrine Florquin (AMC, Amsterdam)
Pathology of rejectionInterleukin-17 positive cells accumulate in renal allograftsduring acute rejection and are independent predictors of worse graft outcome. Yapici U et al. Transplant International 24 (2011) 1008–1017abstract





Luuk Hilbrands


Luuk Hilbrands (Radboudumc, Nijmegen) Immunosuppression
Better to circumvent the use of immunosuppressive drugs: developing an induction therapy by depleting lymphocytes.





New regimens of immunosuppressive drugs

New regimens of immunosuppressive drugs: Everolimus-based, calcineurin-inhibitor-free regimen in recipients of de-novo kidney transplants: an open-label, randomised, controlled trial. Budde et al. Lancet. 2011: 5;377(9768):837-47. Abstract 




David Sachs


David Sachs (Massachusetts General Hospital, Boston, USA) Translational aspects of transplantation tolerance.“Everything is impossible untill you do it. It is always possible to imagine problems.








Combined kidney and bone marrow transplantation. Mixed chimaera with donor for patients who did not want to be on immunosuppressive pills in the rest of their life. For some patients reality:HLA-Mismatched renal transplantation without maintenance immunosuppression. T. Kawai, D. Sachs, M. Sykes, N Engl J Med. 2013; 368(19): 1850–1852. Abstract



Marry de Klerk



Marry de Klerk (Erasmus MC, Rotterdam) and Frank Dor 
Since 2002 the numbers of living donors have increased strongly. In 2014, more living donors than dead donors are counted in the Netherlands.The Dutch Transplantation Foundation coordinates an exchange program of pairs of donors and recipients. From 2004 till 2014, 614 pairs entered the program. 298 were matched, and 199 kidneys were donated.



Discussion about the shortage of donors



Discussion about the shortage of donors 
Presumed consentfor organ donation goes against the principle of autonomy. Public voted: 29% false, 71% true. Prof. Inez de Beaufort: false, once you are dead you have no autonomy.




vraag best solution









FederaAward winners 2014


FederaAward winners 2014
Kathryn Wood
David Sachs





Voorzitters van de programmacommissie
Prof. dr. Frans H.J. Claas, Nederlandse Vereniging voor Immunologie (NVVI) ...meer over Claas 
Dr. Luc J.W. van der Laan, Nederlandse Transplantatie Vereniging (NTV) ...meer over Van der Laan

Een mix en match uit immunologie en transplantatie. 


Een FederaDag is een dag in de frontlinie van de biomedische wetenschap.

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